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The M1 phenotype is often associated with disease, resulting in production and secretion of pro-inflammatory cytokines (i.e., tumor necrosis factor-alpha (TNFα), interleukin-1 β (IL-1β), and IL-6), chemokines, and ROS to neutralize pathogens and increase cell recruitment to the site of inflammation

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[DOI] [PubMed] [Google Scholar] Leaf DE, Body SC, Muehlschlegel JD, McMahon GM, Lichtner P, Collard CD, Shernan SK, Fox AA, Waikar SS